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HLA-B27 By PCR | Human Leukocyte Antigen B27

HLA-B27 By PCR | Human Leukocyte Antigen B27

₹4,863.00Price

 

  • Overview

    USEFUL FOR 
     

    Assisting in the diagnostic process of ankylosing spondylitis, juvenile rheumatoid arthritis, and Reiter syndrome

    METHOD NAME 
     

    Polymerase Chain Reaction ( PCR )

    REPORTING NAME 
     
    HLA-B27 PCR

     

    ALIASES 
     

    B27

    Histocompatibility Antigen

    Human Leukocyte Antigen

    Leukocyte Antigens

    LY27

    Spondylitis

    W-27 (HLA-B27)

  • Specimen

    SPECIMEN TYPE 
     

    Whole Blood EDTA

    SPECIMEN REQUIRED 
     

    Specimen must arrive within 96 hours of draw.

     

    Container/Tube: Lavender top (EDTA)

    Specimen Volume: 6 mL

    Collection Instructions: Do not transfer blood to other containers.

    SPECIMEN MINIMUM VOLUME 
     

    1 mL

  • Clinical Info

    USEFUL FOR 
     

    Assisting in the diagnostic process of ankylosing spondylitis, juvenile rheumatoid arthritis, and Reiter syndrome

    CLINICAL INFORMATION 
     

    This major histocompatibility coded class I antigen is associated with ankylosing spondylitis, juvenile rheumatoid arthritis, and Reiter syndrome. The mechanism of the association is not understood but probably is that of linkage disequilibrium.

     

    There is an increased prevalence of HLA-B27 in certain rheumatic diseases, particularly ankylosing spondylitis.

     

    Studies have demonstrated that the B*27:06 allele, which is present in a small percentage of individuals of Asian ethnicity, may not be associated with ankylosing spondylitis.

    REFERENCE VALUES 
     

    An interpretive report will be provided.

    INTERPRETATION 
     

    Approximately 8% of the normal population carries the HLA-B27 antigen.

     

    HLA-B27 is present in approximately 89% of patients with ankylosing spondylitis, 79% of patients with Reiter syndrome, and 42% of patients with juvenile rheumatoid arthritis. However, lacking other data, it is not diagnostic for these disorders.

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