HLA-B27, Flow Cytometry, Blood

USEFUL FOR 

Assisting in the diagnostic process of ankylosing spondylitis, juvenile rheumatoid arthritis, and Reiter syndrome

METHOD NAME 

Flow Cytometry

REPORTING NAME 

HLA-B27, B

ALIASES 

B27

Histocompatibility Antigen

Human Leukocyte Antigen

Leukocyte Antigens

LY27

Spondylitis

W-27 (HLA-B27)

SPECIMEN TYPE 

SPECIMEN REQUIRED 

Specimen must arrive within 96 hours of draw.

 

Container/Tube: Lavender top (EDTA)

Specimen Volume: 6 mL

Collection Instructions: Do not transfer blood to other containers.

SPECIMEN MINIMUM VOLUME 

1 mL

USEFUL FOR 

Assisting in the diagnostic process of ankylosing spondylitis, juvenile rheumatoid arthritis, and Reiter syndrome

CLINICAL INFORMATION 

This major histocompatibility coded class I antigen is associated with ankylosing spondylitis, juvenile rheumatoid arthritis, and Reiter syndrome. The mechanism of the association is not understood but probably is that of linkage disequilibrium.

 

There is an increased prevalence of HLA-B27 in certain rheumatic diseases, particularly ankylosing spondylitis.

 

Studies have demonstrated that the B*27:06 allele, which is present in a small percentage of individuals of Asian ethnicity, may not be associated with ankylosing spondylitis.

REFERENCE VALUES 

An interpretive report will be provided.

INTERPRETATION 

Approximately 8% of the normal population carries the HLA-B27 antigen.

 

HLA-B27 is present in approximately 89% of patients with ankylosing spondylitis, 79% of patients with Reiter syndrome, and 42% of patients with juvenile rheumatoid arthritis. However, lacking other data, it is not diagnostic for these disorders.