Terminal Deoxynucleotidyl Transferase

Classification of leukemias or lymphomas

For the initial technical component only immunohistochemical (IHC) stain performed, the appropriate bill-only test ID will be reflexed and charged (IHTOI). For each additional technical component only IHC stain performed, an additional bill-only test ID will be reflexed and charged (IHTOA).

Immunohistochemistry

ISTDTIHCTO

For the initial technical component only immunohistochemical (IHC) stain performed, the appropriate bill-only test ID will be reflexed and charged (IHTOI). For each additional technical component only IHC stain performed, an additional bill-only test ID will be reflexed and charged (IHTOA).

This test includes only technical performance of the stain (no pathologist interpretation is performed). If diagnostic consultation by a pathologist is required order PATHC / Pathology Consultation.

Attach the green pathology address label and the pink Immunostain Technical Only label included in the kit to the outside of the transport container.

Supplies: Immunostain Technical Only Envelope (T693)

Specimen Type: Tissue

Preferred: 2 Unstained positively charged glass slide (25- x 75- x 1-mm) per test ordered; sections 4-microns thick.

Acceptable: Formalin-fixed, paraffin-embedded (FFPE) tissue block

Classification of leukemias or lymphomas

For the initial technical component only immunohistochemical (IHC) stain performed, the appropriate bill-only test ID will be reflexed and charged (IHTOI). For each additional technical component only IHC stain performed, an additional bill-only test ID will be reflexed and charged (IHTOA).

Terminal deoxynucleotidyl transferase (TdT) is a nuclear enzyme that adds individual nucleotides to the termini of DNA strands without the use of a DNA template. TdT is expressed normally in cortical thymocytes, immature hematopoietic stem cells, and B and T lymphoblasts. Diagnostically, TdT positivity can be helpful in confirming a diagnosis of lymphoblastic lymphoma or leukemia. Acute myeloid leukemias can also express TdT.

This test includes only technical performance of the stain (no pathologist interpretation is performed). If an interpretation is needed, refer to PATHC / Pathology Consultation for a full diagnostic evaluation or second opinion of the case. All material associated with the case is required.

. If a control tissue is not included on the slide, a scanned image of the relevant quality control tissue is available upon request. Contact 855-516-8404.

Interpretation of this test should be performed in the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.